Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

HTRA1

Gene Name

HtrA serine peptidase 1

Gene ID

5654

Gene Synonyms

ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11

ORF Size

1443 bp

RefSeq#

BC172536

Gene Description

HTRA1 encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.

UniGene ID

Hs.501280

HGNC ID

HGNC:9476