Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

GRB2

Gene Name

growth factor receptor bound protein 2

Gene ID

2885

Gene Synonyms

ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2

ORF Size

654 bp

RefSeq#

BC000631

Gene Description

GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.444356

HGNC ID

HGNC:4566