Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

ETF1

Gene Name

eukaryotic translation termination factor 1

Gene ID

2107

Gene Synonyms

D5S1995; ERF; ERF1; RF1; SUP45L1; TB3-1

ORF Size

1314 bp

RefSeq#

BC088358

Gene Description

ETF1 encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in coding and non-coding transcript variants. Pseudogenes of this gene are found on chromosomes 5, 7 and X.

UniGene ID

Hs.483494

HGNC ID

HGNC:3477