rat TNF Over-expression AAV

Cat. No: AAV-294787

Availability: Immediate

Name: AAV-r-TNF

This is an AAV expressing Rat Tnf.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Tnf
Gene Name: tumor necrosis factor
Gene ID: 24835
Gene Synonyms: RATTNF; TNF-alpha; Tnfa
ORF Size: 708 bp
RefSeq#: BC107671
Gene Description: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation|Function: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.