rat CDKN1A Over-expression AAV

Cat. No: AAV-294363

Availability: 3-5 weeks

Name: AAV-r-CDKN1A

This is an AAV expressing Rat Cdkn1a.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Cdkn1a
Gene Name: cyclin-dependent kinase inhibitor 1A
Gene ID: 114851
Gene Synonyms: Cip1; UV96; Waf1
ORF Size: 495 bp
RefSeq#: BC100620
Gene Description: CDKN1A may be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.