rat DNM1L Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-292343
Availability:
3-5 weeks
Name:
AAV-r-DNM1L
This is an AAV expressing Rat Dnm1l.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Rat
- Gene Symbol
- Dnm1l
- Gene Name
- dynamin 1-like
- Gene ID
- 114114
- Gene Synonyms
- DLP1; Dnml1; Drp1
- ORF Size
- 2151 bp
- RefSeq#
- BC085843
- Gene Description
- Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport|Function: Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.
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