mouse DNAJA3 Over-expression AAV

Cat. No: AAV-275968

Availability: 3-5 weeks

Name: AAV-m-DNAJA3

This is an AAV expressing Mouse Dnaja3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dnaja3
Gene Name: DnaJ heat shock protein family (Hsp40) member A3
Gene ID: 83945
Gene Synonyms: 1200003J13Rik; 1810053A11Rik; C81173; Tid-1; Tid1l
ORF Size: 1362 bp
RefSeq#: BC027240
Gene Description: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
UniGene ID: Mm.248337