mouse UNC5B Over-expression AAV

Cat. No: AAV-275637

Availability: 3-5 weeks

Name: AAV-m-UNC5B

This is an AAV expressing Mouse Unc5b.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Unc5b
Gene Name: unc-5 netrin receptor B
Gene ID: 107449
Gene Synonyms: 6330415E02Rik; A630020F16; D10Bwg0792e; Unc5h2
ORF Size: 2805 bp
RefSeq#: BC057560
Gene Description: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
UniGene ID: Mm.290433