mouse TLR4 Over-expression AAV

Cat. No: AAV-274280

Availability: 3-5 weeks

Name: AAV-m-TLR4

This is an AAV expressing Mouse Tlr4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Tlr4
Gene Name: toll-like receptor 4
Gene ID: 21898
Gene Synonyms: Lps; Ly87; Ran/M1; Rasl2-8
ORF Size: 2508 bp
RefSeq#: BC029856
Gene Description: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.
UniGene ID: Mm.38049