mouse SRGAP2 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-273138
Availability:
3-5 weeks
Name:
AAV-m-SRGAP2
This is an AAV expressing Mouse Srgap2.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Srgap2
- Gene Name
- SLIT-ROBO Rho GTPase activating protein 2
- Gene ID
- 14270
- Gene Synonyms
- 9930124L22Rik; AI448945; FBP2; Fnbp2; srGAP3
- ORF Size
- 3291 bp
- RefSeq#
- BC152935
- Gene Description
- RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
- UniGene ID
- Mm.476747
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