mouse RPE65 Over-expression AAV

Cat. No: AAV-270828

Availability: 3-5 weeks

Name: AAV-m-RPE65

This is an AAV expressing Mouse Rpe65.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Rpe65
Gene Name: retinal pigment epithelium 65
Gene ID: 19892
Gene Synonyms: 65kDa; A930029L06Rik; LCA2; Mord1; rd12; RP20
ORF Size: 1602 bp
RefSeq#: BC130028
Gene Description: Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
UniGene ID: Mm.131708