mouse PRF1 Over-expression AAV

Cat. No: AAV-269342

Availability: 3-5 weeks

Name: AAV-m-PRF1

This is an AAV expressing Mouse Prf1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Prf1
Gene Name: perforin 1 (pore forming protein)
Gene ID: 18646
Gene Synonyms: Pfn; Pfp; Prf-1
ORF Size: 1665 bp
RefSeq#: BC132300
Gene Description: Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
UniGene ID: Mm.240313