mouse NACA Over-expression AAV

Cat. No: AAV-265394

Availability: 3-5 weeks

Name: AAV-m-NACA

This is an AAV expressing Mouse Naca.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Naca
Gene Name: nascent polypeptide-associated complex alpha polypeptide
Gene ID: 17938
Gene Synonyms: AL022831; AL024382; Gm1878; mKIAA0363; skNAC
ORF Size: 648 bp
RefSeq#: BC099375
Gene Description: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
UniGene ID: Mm.3746