mouse FBXO11 Over-expression AAV

Cat. No: AAV-259221

Availability: 3-5 weeks

Name: AAV-m-FBXO11

This is an AAV expressing Mouse Fbxo11.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Fbxo11
Gene Name: F-box protein 11
Gene ID: 225055
Gene Synonyms: C80048; Jf
ORF Size: 2529 bp
RefSeq#: BC117884
Gene Description: Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
UniGene ID: Mm.386857