mouse DKK3 Over-expression AAV

Cat. No: AAV-257208

Availability: 3-5 weeks

Name: AAV-m-DKK3

This is an AAV expressing Mouse Dkk3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dkk3
Gene Name: dickkopf WNT signaling pathway inhibitor 3
Gene ID: 50781
Gene Synonyms: AW061014; C87148
ORF Size: 1050 bp
RefSeq#: BC050934
Gene Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
UniGene ID: Mm.55143