mouse DAPK2 Over-expression AAV

Cat. No: AAV-256805

Availability: 3-5 weeks

Name: AAV-m-DAPK2

This is an AAV expressing Mouse Dapk2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dapk2
Gene Name: death-associated protein kinase 2
Gene ID: 13143
ORF Size: 1113 bp
RefSeq#: BC022165
Gene Description: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation|Function: Isoform 2 can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
UniGene ID: Mm.335252