mouse ADAR Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-252106
Availability:
3-5 weeks
Name:
AAV-m-ADAR
This is an AAV expressing Mouse Adar.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Adar
- Gene Name
- adenosine deaminase, RNA-specific
- Gene ID
- 56417
- Gene Synonyms
- Adar1; Adar1p110; Adar1p150; AV242451; mZaADAR
- ORF Size
- 3459 bp
- RefSeq#
- BC042505
- Gene Description
- Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
- UniGene ID
- Mm.316628
Related Products
Product | Cat No. |
---|---|
Ad-h-ADAR | ADV-200406 |
Ad-m-ADAR | ADV-252106 |
AAV-h-ADAR-shRNA | shAAV-200406 |
AAV-m-ADAR-shRNA | shAAV-252106 |
Ad-h-ADAR-shRNA | shADV-200406 |
Ad-m-ADAR-shRNA | shADV-252106 |
Control Products
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