human UNC13D Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-227185
Availability:
3-5 weeks
Name:
AAV-h-UNC13D
This is an AAV expressing Human UNC13D.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- UNC13D
- Gene Name
- unc-13 homolog D
- Gene ID
- 201294
- Gene Synonyms
- FHL3; HLH3; HPLH3; Munc13-4
- ORF Size
- 3273 bp
- RefSeq#
- BC067084
- Gene Description
- UNC13D encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
- UniGene ID
- Hs.41045
- HGNC ID
- HGNC:23147
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