human TINF2 Over-expression AAV

Cat. No: AAV-225537

Availability: 3-5 weeks

Name: AAV-h-TINF2

This is an AAV expressing Human TINF2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TINF2
Gene Name: TERF1 interacting nuclear factor 2
Gene ID: 26277
Gene Synonyms: DKCA3; TIN2
ORF Size: 1356 bp
RefSeq#: BC005030
Gene Description: TINF2 encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.
UniGene ID: Hs.496191
HGNC ID: HGNC:11824