human STRADA Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-224633
Availability:
3-5 weeks
Name:
AAV-h-STRADA
This is an AAV expressing Human STRADA.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- STRADA
- Gene Name
- STE20-related kinase adaptor alpha
- Gene ID
- 92335
- Gene Synonyms
- LYK5; NY-BR-96; PMSE; Stlk; STRAD
- ORF Size
- 705 bp
- RefSeq#
- BC043641
- Gene Description
- STRADA contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
- UniGene ID
- Hs.514402
- HGNC ID
- HGNC:30172
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