human RRM2B Over-expression AAV

Cat. No: AAV-222005

Availability: 3-5 weeks

Name: AAV-h-RRM2B

This is an AAV expressing Human RRM2B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RRM2B
Gene Name: ribonucleotide reductase regulatory TP53 inducible subunit M2B
Gene ID: 50484
Gene Synonyms: MTDPS8A; MTDPS8B; P53R2
ORF Size: 1056 bp
RefSeq#: BC130628
Gene Description: RRM2B encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.
UniGene ID: Hs.512592
HGNC ID: HGNC:17296