human RNF20 Over-expression AAV

Cat. No: AAV-221398

Availability: 3-5 weeks

Name: AAV-h-RNF20

This is an AAV expressing Human RNF20.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RNF20
Gene Name: ring finger protein 20
Gene ID: 56254
Gene Synonyms: BRE1; BRE1A; hBRE1
ORF Size: 2928 bp
RefSeq#: BC152309
Gene Description: RNF20 shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
UniGene ID: Hs.656088
HGNC ID: HGNC:10062