human RNF170 Over-expression AAV

Cat. No: AAV-221377

Availability: 3-5 weeks

Name: AAV-h-RNF170

This is an AAV expressing Human RNF170.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RNF170
Gene Name: ring finger protein 170
Gene ID: 81790
Gene Synonyms: ADSA; SNAX1
ORF Size: 603 bp
RefSeq#: BC032393
Gene Description: RNF170 encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.
UniGene ID: Hs.696153
HGNC ID: HGNC:25358