human RANGAP1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-220709
Availability:
3-5 weeks
Name:
AAV-h-RANGAP1
This is an AAV expressing Human RANGAP1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- RANGAP1
- Gene Name
- Ran GTPase activating protein 1
- Gene ID
- 5905
- Gene Synonyms
- Fug1; RANGAP; SD
- ORF Size
- 1764 bp
- RefSeq#
- BC014044
- Gene Description
- RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
- UniGene ID
- Hs.183800
- HGNC ID
- HGNC:9854
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