human PROZ Over-expression AAV

Cat. No: AAV-219944

Availability: 3-5 weeks

Name: AAV-h-PROZ

This is an AAV expressing Human PROZ.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PROZ
Gene Name: protein Z, vitamin K dependent plasma glycoprotein
Gene ID: 8858
Gene Synonyms: PZ
ORF Size: 1203 bp
RefSeq#: BC074907
Gene Description: PROZ encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.
UniGene ID: Hs.1011
HGNC ID: HGNC:9460