human PNPO Over-expression AAV

Cat. No: AAV-219322

Availability: 3-5 weeks

Name: AAV-h-PNPO

This is an AAV expressing Human PNPO.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PNPO
Gene Name: pyridoxamine 5'-phosphate oxidase
Gene ID: 55163
Gene Synonyms: HEL-S-302; PDXPO
ORF Size: 786 bp
RefSeq#: BC006525
Gene Description: The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.
UniGene ID: Hs.631742
HGNC ID: HGNC:30260