human PMVK Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-219282
Availability:
3-5 weeks
Name:
AAV-h-PMVK
This is an AAV expressing Human PMVK.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- PMVK
- Gene Name
- phosphomevalonate kinase
- Gene ID
- 10654
- Gene Synonyms
- HUMPMKI; PMK; PMKA; PMKASE; POROK1
- ORF Size
- 579 bp
- RefSeq#
- BC006089
- Gene Description
- PMVK encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
- UniGene ID
- Hs.30954
- HGNC ID
- HGNC:9141
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