human PLOD3 Over-expression AAV

Cat. No: AAV-219220

Availability: 3-5 weeks

Name: AAV-h-PLOD3

This is an AAV expressing Human PLOD3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PLOD3
Gene Name: procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Gene ID: 8985
Gene Synonyms: LH3
ORF Size: 2217 bp
RefSeq#: BC011674
Gene Description: PLOD3 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.
UniGene ID: Hs.153357
HGNC ID: HGNC:9083