human PKN1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-219040
Availability:
3-5 weeks
Name:
AAV-h-PKN1
This is an AAV expressing Human PKN1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- PKN1
- Gene Name
- protein kinase N1
- Gene ID
- 5585
- Gene Synonyms
- DBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1
- ORF Size
- 1812 bp
- RefSeq#
- BC094766
- Gene Description
- PKN1 belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- UniGene ID
- Hs.466044
- HGNC ID
- HGNC:9405
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