human PKM2 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-219036
Availability:
3-5 weeks
Name:
AAV-h-PKM2
This is an AAV expressing Human PKM.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- PKM
- Gene Name
- pyruvate kinase, muscle
- Gene ID
- 5315
- Gene Synonyms
- CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1
- ORF Size
- 1101 bp
- RefSeq#
- BC094767
- Gene Description
- PKM encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
- UniGene ID
- Hs.534770
- HGNC ID
- HGNC:9021
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