human PKM2 Over-expression AAV

Cat. No: AAV-219032

Availability: 3-5 weeks

Name: AAV-h-PKM2

This is an AAV expressing Human PKM.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PKM
Gene Name: pyruvate kinase, muscle
Gene ID: 5315
Gene Synonyms: CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1
ORF Size: 1596 bp
RefSeq#: BC007952
Gene Description: PKM encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
UniGene ID: Hs.534770
HGNC ID: HGNC:9021