human PCSK2 Over-expression AAV

Cat. No: AAV-218411

Availability: 3-5 weeks

Name: AAV-h-PCSK2

This is an AAV expressing Human PCSK2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PCSK2
Gene Name: proprotein convertase subtilisin/kexin type 2
Gene ID: 5126
Gene Synonyms: NEC 2; NEC-2; NEC2; PC2; SPC2
ORF Size: 1860 bp
RefSeq#: BC040546
Gene Description: PCSK2 encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. PCSK2 may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniGene ID: Hs.315186
HGNC ID: HGNC:8744