human OTX2 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-218011
Availability:
3-5 weeks
Name:
AAV-h-OTX2
This is an AAV expressing Human OTX2.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- OTX2
- Gene Name
- orthodenticle homeobox 2
- Gene ID
- 5015
- Gene Synonyms
- CPHD6; MCOPS5
- ORF Size
- 894 bp
- RefSeq#
- BC032579
- Gene Description
- OTX2 encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). OTX2 is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.
- UniGene ID
- Hs.288655
- HGNC ID
- HGNC:8522
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