human NR1I2 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-217039
Availability:
3-5 weeks
Name:
AAV-h-NR1I2
This is an AAV expressing Human NR1I2.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- NR1I2
- Gene Name
- nuclear receptor subfamily 1 group I member 2
- Gene ID
- 8856
- Gene Synonyms
- BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
- ORF Size
- 1302 bp
- RefSeq#
- BC017304
- Gene Description
- NR1I2 product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
- UniGene ID
- Hs.7303
- HGNC ID
- HGNC:7968
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