human NR1H3 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-217036
Availability:
3-5 weeks
Name:
AAV-h-NR1H3
This is an AAV expressing Human NR1H3.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- NR1H3
- Gene Name
- nuclear receptor subfamily 1 group H member 3
- Gene ID
- 10062
- Gene Synonyms
- LXR-a; LXRA; RLD-1
- ORF Size
- 1209 bp
- RefSeq#
- BC041172
- Gene Description
- NR1H3 belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- UniGene ID
- Hs.438863
- HGNC ID
- HGNC:7966
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