human MAP3K12 Over-expression AAV

Cat. No: AAV-214926

Availability: 3-5 weeks

Name: AAV-h-MAP3K12

This is an AAV expressing Human MAP3K12.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MAP3K12
Gene Name: mitogen-activated protein kinase kinase kinase 12
Gene ID: 7786
Gene Synonyms: DLK; MEKK12; MUK; ZPK; ZPKP1
ORF Size: 1704 bp
RefSeq#: BC050050
Gene Description: MAP3K12 encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
UniGene ID: Hs.713539
HGNC ID: HGNC:6851