human LCK Over-expression AAV

Cat. No: AAV-213750

Availability: 3-5 weeks

Name: AAV-h-LCK

This is an AAV expressing Human LCK.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: LCK
Gene Name: LCK proto-oncogene, Src family tyrosine kinase
Gene ID: 3932
Gene Synonyms: IMD22; LSK; p56lck; pp58lck; YT16
ORF Size: 1620 bp
RefSeq#: BC013200
Gene Description: LCK is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
UniGene ID: Hs.470627
HGNC ID: HGNC:6524