human KCNN2 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-212766
Availability:
3-5 weeks
Name:
AAV-h-KCNN2
This is an AAV expressing Human KCNN2.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- KCNN2
- Gene Name
- potassium calcium-activated channel subfamily N member 2
- Gene ID
- 3781
- Gene Synonyms
- hSK2; KCa2.2; SK2; SKCa 2; SKCA2
- ORF Size
- 1740 bp
- RefSeq#
- BC117456
- Gene Description
- Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
- UniGene ID
- Hs.98280
- HGNC ID
- HGNC:6291
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