human ITM2B Over-expression AAV

Cat. No: AAV-212536

Availability: 3-5 weeks

Name: AAV-h-ITM2B

This is an AAV expressing Human ITM2B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ITM2B
Gene Name: integral membrane protein 2B
Gene ID: 9445
Gene Synonyms: ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; imBRI2; RDGCA
ORF Size: 801 bp
RefSeq#: BC016148
Gene Description: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
UniGene ID: Hs.643683
HGNC ID: HGNC:6174