human GBA Over-expression AAV

Cat. No: AAV-209700

Availability: Immediate

Name: AAV-h-GBA

This is an AAV expressing Human GBA.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GBA
Gene Name: glucosylceramidase beta
Gene ID: 2629
Gene Synonyms: GBA1; GCB; GLUC
ORF Size: 1611 bp
RefSeq#: BC003356
Gene Description: GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
UniGene ID: Hs.282997
HGNC ID: HGNC:4177