human GADD45B Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-209542
Availability:
3-5 weeks
Name:
AAV-h-GADD45B
This is an AAV expressing Human GADD45B.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- GADD45B
- Gene Name
- growth arrest and DNA damage inducible beta
- Gene ID
- 4616
- Gene Synonyms
- GADD45BETA; MYD118
- ORF Size
- 483 bp
- RefSeq#
- BC113466
- Gene Description
- GADD45B is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
- UniGene ID
- Hs.110571
- HGNC ID
- HGNC:4096
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