human EBP Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-207519
Availability:
3-5 weeks
Name:
AAV-h-EBP
This is an AAV expressing Human EBP.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- EBP
- Gene Name
- emopamil binding protein (sterol isomerase)
- Gene ID
- 10682
- Gene Synonyms
- CDPX2; CHO2; CPX; CPXD; MEND
- ORF Size
- 693 bp
- RefSeq#
- BC001549
- Gene Description
- EBP is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist (3H)emopamil and the photoaffinity label (3H)azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
- UniGene ID
- Hs.30619
- HGNC ID
- HGNC:3133
Related Products
Product | Cat No. |
---|---|
AAV-m-EBP | AAV-257715 |
Ad-h-EBP | ADV-207519 |
Ad-m-EBP | ADV-257715 |
AAV-h-EBP-shRNA | shAAV-207519 |
AAV-m-EBP-shRNA | shAAV-257715 |
Ad-h-EBP-shRNA | shADV-207519 |
Ad-m-EBP-shRNA | shADV-257715 |
Control Products
Vector Biolabs
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