human SLC12A1 Over-expression AAV

Cat. No: AAV-206289

Availability: 3-5 weeks

Name: AAV-h-SLC12A1

This is an AAV expressing Human SLC12A1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SLC12A1
Gene Name: solute carrier family 12 member 1
Gene ID: 6557
Gene Synonyms: BSC1; NKCC2
ORF Size: 3297 bp
RefSeq#: BC148651
Gene Description: SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
UniGene ID: Hs.123116
HGNC ID: HGNC:10910