human CRKL Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-206021
Availability:
3-5 weeks
Name:
AAV-h-CRKL
This is an AAV expressing Human CRKL.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CRKL
- Gene Name
- CRK like proto-oncogene, adaptor protein
- Gene ID
- 1399
- ORF Size
- 912 bp
- RefSeq#
- BC043500
- Gene Description
- CRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
- UniGene ID
- Hs.592205
- HGNC ID
- HGNC:2363
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