human CCL5 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-204464
Availability:
3-5 weeks
Name:
AAV-h-CCL5
This is an AAV expressing Human CCL5.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CCL5
- Gene Name
- C-C motif chemokine ligand 5
- Gene ID
- 6352
- Gene Synonyms
- D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228
- ORF Size
- 276 bp
- RefSeq#
- BC008600
- Gene Description
- CCL5 is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
- UniGene ID
- Hs.514821
- HGNC ID
- HGNC:10632
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