Viral Details

Viral Backbone

Recombinant AAV

AAV-ITR

AAV2

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Gene Details

Species

Human

Gene Symbol

CBFA2T3

Gene Name

CBFA2/RUNX1 translocation partner 3

Gene ID

863

Gene Synonyms

ETO2; MTG16; MTGR2; RUNX1T3; ZMYND4

ORF Size

1962 bp

RefSeq#

BC047019

Gene Description

CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. CBFA2T3 is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

UniGene ID

Hs.513811

HGNC ID

HGNC:1537