human CARD8 Over-expression AAV

Cat. No: AAV-204088

Availability: 3-5 weeks

Name: AAV-h-CARD8

This is an AAV expressing Human CARD8.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CARD8
Gene Name: caspase recruitment domain family member 8
Gene ID: 22900
Gene Synonyms: CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN
ORF Size: 1464 bp
RefSeq#: BC045539
Gene Description: CARD8 belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
UniGene ID: Hs.655940
HGNC ID: HGNC:17057