human ACMSD Over-expression AAV

Cat. No: AAV-200194

Availability: 3-5 weeks

Name: AAV-h-ACMSD

This is an AAV expressing Human ACMSD.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACMSD
Gene Name: aminocarboxymuconate semialdehyde decarboxylase
Gene ID: 130013
ORF Size: 1011 bp
RefSeq#: BC107420
Gene Description: The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.(supplied by OMIM, Oct 2004)
UniGene ID: Hs.655728
HGNC ID: HGNC:19288