AAV-Cre (AAV serotype 5) AAV
Cat. No: 7012
Availability:
Immediate
Name:
AAV5-Cre
This AAV serotype 5 virus (Capsid from AAV5 and ITR from AAV2) expresses Cre Recombinase under the control of a CMV promoter. This Cre contains a nuclear localization signal (NLS).
Cre recombinase is a Type I topoisomerase from P1 bacteriophage that catalyzes site-specific recombination of DNA between loxP sites. loxP is a 34 bp DNA sequence at which confers directionality. Cre recombinase is used as a tool to genetically modify genes, such as to delete a segment of DNA flanked by LoxP sites in cultured cells or experimental animals.
$495.00
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- AAV5
- Promoter
- CMV (ubiquitous)
- Storage Buffer
- PBS/5% Glycerol
- Volume
- 20ul
- Titer
- 1x10^13 GC/ml
Gene Details
- Gene Symbol
- Cre Recombinase
Product Citations
This product is referenced in the following publications:
- Anthony, TE. etc (2014). Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit. Cell.
- Gonzalo Viana Di Prisco, etc (2014). Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a. Nature Neuroscience.
- Melanie A Samuel, etc (2014). LKB1 and AMPK regulate synaptic remodeling in old age. Nature Neuroscience.
- W Huang, etc (2016). Translational control by eIF2a phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine. eLife.
- von Schimmelmann M, etc (2016). Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration. Nat Neurosci.
- Placzek AN, etc (2016). eIF2a-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons. eLife.
- L Sun, etc (2020). Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice. Science Bulletin.
- D Kargl, etc (2020). The amygdala instructs insular feedback for affective learning. eLIFE.
Related Products
| Product | Cat No. |
|---|---|
| AAV1-Cre | 7010 |
| AAV2-Cre | 7011 |
| AAV6-Cre | 7013 |
| AAV9-Cre | 7014 |
| AAV1-Cre-GFP | 7015 |
| AAV2-Cre-GFP | 7016 |
| AAV5-Cre-GFP | 7018 |
| AAV6-Cre-GFP | 7019 |
| AAV9-Cre-GFP | 7020 |
| AAV8-Cre | 7060 |
Control Products
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