human BCL-xL shRNA Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: 1808
Availability:
Immediate
Name:
Ad-h-BCL-xL-shRNA
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human BCL-xL gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this human gene was validated by western blot in A549 cells.
The knockdown of this human gene was validated by western blot in A549 cells.
$995.00
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Product Info
- Knockdown
- >80% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6 ()
- Reporter
- eGFP
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- Volume
- 200ul
- Titer
- 1x10^10 PFU/ml
Gene Details
- Species
- Human
- Gene Symbol
- BCL-xL
- Gene ID
- 598
- RefSeq#
- NM_138578
Product Citations
This product is referenced in the following publications:
- Hossein A Hamed, etc (2013). Histone Deacetylase Inhibitors Interact with MDA-7/IL-24 to Kill Primary Human Glioblastoma Cells. Molecular Pharmacology.
- Yacoub, A., etc. (2008). Regulation Of Gst-Mda-7 Toxicity In Human Glioblastoma Cells By Erbb1, Erk1/2, Pi3k, And Jnk1-3 Pathway Signaling. Molecular Cancer Therapeutics.
- Zhang, G., etc. (2008). Vorinostat And Sorafenib Synergistically Kill Tumor Cells Via Flip Suppression And Cd95 Activation. Clinical Cancer Research.
- Park MA, etc (2008). Vorinostat And Sorafenib Increase Er Stress, Autophagy And Apoptosis Via Ceramide-Dependent Cd95 And Perk Activation. Cancer Biol Ther.
- Park MA, etc (2009). Mek1/2 Inhibitors And 17AAG Synergize To Kill Human Gi Tumor Cells In Vitro Via Suppression Of C-Flip-S Levels And Activation Of Cd95. Mol Cancer Ther.
- Walker T, etc (2009). Sorafenib And Vorinostat Kill Colon Cancer Cells By Cd95-Dependent And -Independent Mechanisms. Mol Pharmacol.
- Martin, AP. etc (2009). Bcl-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor And Sorafenib Lethality Via Autophagy And Overcome Blockade Of The Extrinsic Pathway To Facilitate Killing. Mol Pharmacol.
- Adly Yacoub (2009). PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Research.
- Adly Yacoub (2009). Cisplatin Enhances Protein Kinase R-Like Endoplasmic Reticulum Kinase- and CD95-Dependent Melanoma Differentiation-Associated Gene-7/Interleukin-24¿Induced Killing in Ovarian Carcinoma Cells. Molecular Pharmacology.
- Bareford MD, etc (2011). Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells. Cancer Research.
- Teneille Walker, ETC (2010). 17AAG and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and ROS. Mol Cancer Ther.
Related Products
Control Products
| Product | Cat No. |
|---|---|
| Ad-GFP-U6-shRNA | 1122 |
| Ad-U6-Luc-RNAi | 1123 |
| Ad-U6-RNAi | 1640 |
| Ad-U6-shRNA-CFP | 1780 |
| Ad-U6-shRNA-mCherry | 1781 |
| Ad-U6-shRNA-RFP | 1782 |
| Ad-U6-shRNA-YFP | 1783 |
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